According to People magazine and E! News, the 43-year-old Kartheiser, who wed the “Handmaid’s Tale” star in 2014, filed for divorce Aug. 10 in Putnam County, New York.
Bledel, 40, and Kartheiser, best known for his role as Pete Campbell on “Mad Men,” met in 2012 when the former “Gilmore Girls” actress played Campbell’s mistress on the AMC drama, the outlets reported. The pair share one child, a son born in 2015.
Although the couple’s representatives confirmed the split to E!, neither Bledel nor Kartheiser has commented publicly on the news.
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Photos: Alexis Bledel through the years Here are some memorable photos of "Gilmore Girls" and "The Handmaid's Tale" actress Alexis Bledel through the years. (Alberto E. Rodriguez/Getty Images)
Photos: Alexis Bledel through the years 2001: "Gilmore Girls" cast members, left, Yanic Truesdale, Lauren Graham, Kelly Bishop, Alexis Bledel, Keiko Agena and Scott Patterson at the 17th annual TCA Awards held at the Ritz-Carlton Hotel in Huntington, California, on Saturday, July 21, 2001. (Kevin Winter/Getty Images)
Photos: Alexis Bledel through the years 2002: Actress Alexis Bledel poses with actress Lauren Graham during Bledel's 21st birthday party celebration September 23, 2002, at the Big Foot Lodge in Los Feliz, California. (Jon Kopaloff/Getty Images)
Photos: Alexis Bledel through the years 2003: Actress Alexis Bledel attends the ninth annual Screen Actors Guild Awards at the Shrine Auditorium on March 9, 2003, in Los Angeles. (Jon Kopaloff/Getty Images)
Photos: Alexis Bledel through the years 2004: Actress Alexis Bledel watches a model on the runway during the Louis Verdad fashion show at Mercedes Benz Fashion Week in Smashbox Studios on April 2, 2004, in Culver City, California. (Amanda Edwards/Getty Images)
Photos: Alexis Bledel through the years 2005: Actors Blake Lively, Alexis Bledel, Amber Tamblyn and America Ferrera make an appearance at Planet Hollywood to promote their movie "The Sisterhood of the Traveling Pants" on May 25, 2005, in New York City. (Peter Kramer/Getty Images)
Photos: Alexis Bledel through the years 2006: Actor Milo Ventimiglia and actress Alexis Bledel speak during the EIF's Women's Cancer Research Fund honoring Melissa Etheridge at Saks Fifth Avenue's Unforgettable Evening on March 1, 2006, at the Regent Beverly Wilshire Hotel in Beverly Hills, California. (Kevin Winter/Getty Images)
Photos: Alexis Bledel through the years 2006: Actress Alexis Bledel arrives to Mercedes Benz Fashion Week at Smashbox Studios on October 15, 2006, in Culver City, California. (Mark Davis/Getty Images)
Photos: Alexis Bledel through the years 2008: Actresses Blake Lively, Alexis Bledel, America Ferrera and Amber Tamblyn attend the world premiere of "The Sisterhood of the Traveling Pants 2" presented by Warner Bros. Pictures at the Ziegfeld Theatre on July 28, 2008, in New York City. (Stephen Lovekin/Getty Images)
Photos: Alexis Bledel through the years 2009: Actors Alexis Bledel, America Ferrera and Amber Tamblyn attend the "Bang Ditto" book release party at the Bowery Poetry Club on September 3, 2009, in New York City. (Bryan Bedder/Getty Images)
Photos: Alexis Bledel through the years 2010: Actress Alexis Bledel attends the 2010 CFDA Fashion Awards at Alice Tully Hall, Lincoln Center on June 7, 2010, in New York City. (Dimitrios Kambouris/Getty Images)
Photos: Alexis Bledel through the years 2011: Actresses Saoirse Ronan (left) and Alexis Bledel arrive at "Violet & Daisy" Premiere during the 2011 Toronto International Film Festival held at the Elgin theatre on September 15, 2011, in Toronto. (Sonia Recchia/Getty Images)
Photos: Alexis Bledel through the years 2012: Actress Alexis Bledel attends "Regrets" Off-Broadway opening night celebration at Beacon on March 27, 2012, in New York City. (Mike Coppola/Getty Images)
Photos: Alexis Bledel through the years 2013: Actors Vincent Kartheiser (left) and Alexis Bledel arrive at the 19th annual Screen Actors Guild Awards held at the Shrine Auditorium on January 27, 2013, in Los Angeles. (Alberto E. Rodriguez/Getty Images)
Photos: Alexis Bledel through the years 2015: Alexis Bledel, Amber Tamblyn and Questlove attend Amber Tamblyn "Dark Sparkler" Book Release Party at Housing Works Bookstore Cafe on April 6, 2015, in New York City. (Robin Marchant/Getty Images)
Photos: Alexis Bledel through the years 2016: Actors Alexis Bledel and Lauren Graham attend the premiere of Netflix's "Gilmore Girls: A Year in the Life" at the Regency Bruin Theatre on November 18, 2016, in Los Angeles. (Alberto E. Rodriguez/Getty Images)
Photos: Alexis Bledel through the years 2017: Actors Ann Dowd, Elisabeth Moss, and Alexis Bledel, winners of the award for Outstanding Drama Series for "The Handmaid's Tale," attend IMDb LIVE After the Emmys at Microsoft Theater on September 17, 2017, in Los Angeles. (Rich Polk/Getty Images for IMDb)
Photos: Alexis Bledel through the years 2018: Alexis Bledel attends the 29th annual GLAAD Media Awards at The Hilton Midtown on May 5, 2018, in New York City. (J. Merritt/Getty Images for GLAAD)
Photos: Alexis Bledel through the years 2020: Alexis Bledel attends the 26th annual Screen Actors Guild Awards at the Shrine Auditorium on January 19, 2020, in Los Angeles. (Gregg DeGuire/Getty Images for Turner)
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